| Theme | New aspect of calcium, magnesium and phosphate transport -- Basic principles and clinical applications | |
|---|---|---|
| Title | Klotho regulates FGF23 signaling and phosphate / calcium metabolism | |
| Publish Date | 2007/01 | |
| Author | Hiroshi Kurosu | UT Southwestern Medical Center at Dallas, Department of Pathology |
| Author | Makoto Kuro-o | UT Southwestern Medical Center at Dallas, Department of Pathology |
| [ Summary ] | Inorganic phosphate and calcium homeostasis are maintained by the balance between phosphate and calcium (re) absorption and excretion in the kidney, bone, and intestine. This is a highly regulated process with various hormonal factors acting in concert on these tissues. Recent studies have identified fibroblast growth factor-23 (FGF23) as one of these hormonal factors. FGF23 is produced in bone, circulates in the blood, and suppresses phosphate reabsorption in the kidney. Independently of these studies, Klotho has been identified as a factor involved in the regulation of phosphate and calcium homeostasis. This review will focus on the unexpected relation between FGF23 and Klotho, which potentially provides a new insight into the mechanism of FGF signaling regulation and phosphate, calcium and vitamin D metabolism. | |