| Theme | Bone tissue regeneration | |
|---|---|---|
| Title | Designing calcium phosphate ceramics as bone scaffold | |
| Publish Date | 2006/10 | |
| Author | Koji Ioku | Graduate School of Environmental Studies, Tohoku University |
| [ Summary ] | Designing ceramic scaffolds is one of the most important matters concerning regenerative medical techniques for bones. Ceramics, without natural organic compounds, are safe for the human body, especially hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). Therefore, pure ceramic scaffolds should be ideal materials. Strong candidates for bone regeneration scaffold are HA and β-TCP, because the measurement of osteogenic differentiation of the mesenchymal stem cells related to HA and β-TCP showed excellent results, as did tissue culture polystyrene. It is important for HA remaining in scaffolds to become part of the pore structure and help in the control of the crystal line surface, due to it having a high selectivity in the adsorption of proteins. β-TCP is important in the scaffolding mechanism, and the designing of pore structures, due to its control of resorption rate. Further design research on HA and β-TCP is required. |
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