| Theme | Bone tissue regeneration | |
|---|---|---|
| Title | Characterization of bone marrow mesenchymal stem cells | |
| Publish Date | 2006/10 | |
| Author | Yukio Kato | Department of Dental and Medical Biochemistry, Hiroshima University |
| Author | Hiroshi Kubo | Department of Molecular and internal medicine Graduate School of Biomedical Sciences, Hiroshima University |
| Author | Masakazu Shimizu | Department of Molecular and internal medicine Graduate School of Biomedical Sciences, Hiroshima University |
| Author | Akira Igarashi | Department of Molecular and internal medicine Graduate School of Biomedical Sciences, Hiroshima University |
| Author | Koichiro Tsuji | Department of Molecular and internal medicine Graduate School of Biomedical Sciences, Hiroshima University |
| Author | Takeshi Kawamoto | Department of Dental and Medical Biochemistry, Hiroshima University |
| Author | Ayumu Nakashima | TWO CELLS, Co., Ltd. |
| [ Summary ] | Bone marrow mesenchymal stem cells (MSC) have multi-lineage differentiation potential and are resistant to hypoxia. MSC activity may be supported by “stemness” genes, whose expression is modulated by the in vivo location of MSC. Jaw-derived and ilium-derived MSC showed different gene expression profiles and different chondrogenic and adipogenic potentials. MSC may be useful for regenerative medicine to treat some renal diseases. | |