| Theme | New Aspects of Parathyroid Hormone | |
|---|---|---|
| Title | New aspect of PTH molecule in chronic kidney disease | |
| Publish Date | 2006/07 | |
| Author | Motoko Tanaka | Department of Nephrology, Akebono Clinic |
| Author | Masafumi Fukagawa | Division of Nephrology and Dialysis Center, Kobe University School of Medicine |
| [ Summary ] | Measurement of intact-PTH is essential for optimal management of bone abnormalities in patients with chronic kidney disease. The newer PTH assays ; bio-intact-PTH assays and whole-PTH assays, use an antibody that binds only if the first amino acid is present, making it specific to the complete molecule, (1-84) -PTH. Recently, a small number of patients with parathyroid carcinoma, primary hyperparathyroidism and secondary hyperparathyroidism, have been found to have higher (1-84) -PTH concentrations than intact-PTH, along with abnormally high (1-84) -PTH / intact-PTH ratios. In these patients, a new molecular form of 1-84 PTH has been suggested, which cannot be detected by the antibody used in intact PTH assays. |
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