| Theme | Glucocorticoid-induced osteoporosis and bone metabolism | |
|---|---|---|
| Title | Alteration of bone structure in glucocorticoid-induced osteoporosis | |
| Publish Date | 2006/04 | |
| Author | Akinori Sakai | Department of Orthopaedic Surgery, University of Occupational and Environmental Health |
| Author | Satoshi Ikeda | Department of Orthopaedic Surgery, Kenai Kinen Hospital |
| Author | Shojiro Akahoshi | Department of Orthopaedic Surgery, University of Occupational and Environmental Health |
| Author | Toshitaka Nakamura | Department of Orthopaedic Surgery, University of Occupational and Environmental Health |
| [ Summary ] | We described alterations in bone turnoverrates, mass, structure, and mechanical strength in glucocorticoid-induced osteoporosis (GIO). In GIO, bone turnover is low in relation to the reduction of bone formation and resorption. Trabecular bone volume is reduced and trabecular microstructures deteriorate. Cortical width and area are also reduced. The reason why bone fragility occurs more frequently in GIO compared to that seen with postmenopausal osteoporosis, is because cortical bone mass as well as trabecular bone mass is reduced and trabecular microstructures deteriorate. | |