| Theme | Impaired metabolism of bone and calcium in diabetes mellitus | |
|---|---|---|
| Title | Bone and mineral metabolism in diabetics -- Bone mineral density and fracture risk | |
| Publish Date | 2006/01 | |
| Author | Seiji Fukumoto | Division of Nephrology & Endocrinology, Department of Internal Medicine, University of Tokyo Hospital |
| [ Summary ] | Previous studies have indicated that bone mineral density is lower in patients with type I diabetes. In contrast, contradictory results have been published concerning bone mineral density and fracture risks in type II diabetics. Recent large scale clinical studies have revealed that bone mineral density is high in type II diabetics even after adjustments for several contributing factors including age and body mass index. They also have shown that the risk of fractures is high in patients with type II diabetes after adjustments for bone mineral density and age. However, there still remain unanswered questions such as what are the effects of diabetes on bone mass and fracture risk in different races and what are the effects of improvement of glucose metabolism on these parameters. These clinical data, together with results from basic research investigating the mechanisms of the effects of diabetes on bone and mineral metabolism will contribute to the elucidation of the detailed relationship between diabetes and bone metabolism. | |