| Theme | Impaired metabolism of bone and calcium in diabetes mellitus | |
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| Title | Role of hyperglycemia in pathogenesis of diabetic osteopathy | |
| Publish Date | 2006/01 | |
| Author | Kiyoshi Tanaka | Department of Food and Nutrition, Kyoto Women's University |
| [ Summary ] | Diabetic osteopathy is caused by many factors, including hyperglycemia. High concentrations of glucose, which suppresses osteoblastic cell functions, is likely to have clinical significance, since the predominant feature of diabetic osteopathy is decreased bone formation. Excessive glucose exerts detrimental effects on osteoblasts, both directly and through polyol pathways. Recently, another mechanism concerning skeletal glucose toxicity has been suggested : the enhancement of osteoclastic bone resorption. Additionally, hyperglycemia causes glycosuria and increases urinary calcium excretion, resulting in secondary hyperparathyroidism and increased bone resorption. Thus, hyperglycemia affects various aspects of bone and mineral metabolism. The elucidation of the precise pathogenesis of diabetic osteopathy awaits further research. |
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