| Theme | Usefulness of bone biopsy in making a diagnosis of ROD -- Its significance and limits | |
|---|---|---|
| Title | New histomorphometric analysis excluding classic classification of ROD ; Significance of minimodeling mechanism in patients with adynamic bone disease | |
| Publish Date | 2005/10 | |
| Author | Yoshifumi Ubara | Kidney Center, Toranomon Hospital |
| Author | Shohei Nakanishi | Kidney Center, Toranomon Hospital |
| Author | Kei Kadoguchi | Kidney Center, Toranomon Hospital |
| Author | Kenmei Takaichi | Kidney Center, Toranomon Hospital |
| Author | Akemi Itou | Niigata Bone Science Institute |
| Author | Hideaki Takahashi | Niigata Bone Science Institute |
| [ Summary ] | Idiopathic adynamic bone disease (ABD) in dialysis patients is characterized by low serum parathyroid hormone (PTH) concentration. We performed histomorphometric analysis of bone specimens from biopsies of patients with primary hypoparathyroidism and from autopsy specimens of bone from patients with secondary hypoparathyroidism related to long-term hemodialysis. Histomorphometric analysis indicated a diagnosis of ABD. Humplike structures, which have been called “minimodeling” were revealed. Minimodeling might contribute to bone formation in dialysis patients with ABD, in the absence of remodeling stimulated by PTH, especially in relatively young patients with high activity levels in their daily lives. |
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