| Theme | FGF23 as a regulatory factor of bone and mineral metabolism | |
|---|---|---|
| Title | Phosphorus metabolism disorders and FGF23 in chronic kidney disease | |
| Publish Date | 2005/04 | |
| Author | Shohei Nakanishi | The Nephrology Center, Toranomon Hospital |
| Author | Masafumi Fukagawa | Division of Nephrology and Dialysis Center, Kobe University School of Medicine |
| [ Summary ] | FGF23 is a recently discovered cause of hypophosphatemic disease through phosphate wasting and a physiologic factor, related to the regulation of phosphate homeostasis and vitamin D metabolism. FGF23 levels elevate in the early stages of chronic kidney disease, and they exhibit positive correlations with serum phosphate, serum calcium, serum parathyroid hormone levels and negative correlations with 1,25 (OH) 2D3 levels in chronic renal failure. FGF23 levels predicted the development of secondary hyperparathyroidism in hemodialysis patients. | |