| Theme | FGF23 as a regulatory factor of bone and mineral metabolism | |
|---|---|---|
| Title | Phosphate homeostasis and FGF23 | |
| Publish Date | 2005/04 | |
| Author | Ken-ichi Miyamoto | Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author | Hiroko Segawa | Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| Author | Mikiko Ito | Department of Molecular Nutrition, Institution of Health Bioscience, The University of Tokushima, Graduate School |
| [ Summary ] | Serum phosphate concentrations are maintained with in a range by a process that involves the intestinal absorption and renal excretion of inorganic phosphates. The hormones belived to influence these processes are parathyroid hormone (PTH) and the active metabolite of vitamin D [1,25 (OH) 2D]. A new class of phosphate-regulating factor (FGF23), has been shown to be associated with the development of XLH, TIO and ADHR. FGF23 decreases serum phosphate by reducing renal phosphate reabsorption and by suppressing 1,25 (OH) 2D formation through the inhibition of 1 alfa-hydroxylase. However, the role of FGF23 under normal or pathologic conditions is still unknown. | |