| Theme | Progress in the management of phosphorus in chronic kidney disease | |
|---|---|---|
| Title | Effect of reduced calcium overload with sevelamer hydrochloride on adynamic bone disease | |
| Publish Date | 2004/10 | |
| Author | Kanji Shishido | Sekishinkai Kawasaki Clinic |
| Author | Keiko Takahashi | Sekishinkai Kawasaki Clinic |
| Author | Hisatoshi Haizuka | Sekishinkai Kawasaki Clinic |
| Author | Masahiro Nishihara | Sekishinkai Kawasaki Clinic |
| [ Summary ] | Calcium (Ca) overload, which can be induced by administrating Ca-based phosphate (P) binder and active vitamin D (VD) analogs, plays an important role in the pathogenesis of adynamic bone disease. Sevelamer hydrochloride (SH), which is a non-Ca-containing P binder, is expected to reduce Ca overload in the management of renal osteodystrophy, so that SH treatment can improve not only hypoparathyroidism, but also low turnover bone state in dialysis patients. The alleviated bone turnover may contribute to prevention and/or treatment of vascular calcification in dialysis patients. | |