| Theme | Genome analysis in the field of bone metabolism | |
|---|---|---|
| Title | Molecular pathogenesis of primary hyperparathyroidism | |
| Publish Date | 2004/01 | |
| Author | Yasuo Imanishi | Division of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] | Parathyroid adenomas are common benign neoplasms for which their monoclonality have been described. Currently, two genes are established contributors to parathyroid adenomas, the cyclin D1 oncogene and the MEN1 tumor suppressor gene. Recent studies also suggest that DNA mismatch repair system may play a role in the molecular pathogenesis of parathyroid adenomas. | |