| Theme | The impact of bone and Ca/Pi metabolism on vascular disease | |
|---|---|---|
| Title | Treatment of coronary and peripheral arteriosclerosis in dialysis patients | |
| Publish Date | 2003/10 | |
| Author | Tokuichiro Sugimoto | Department of Nephrology, Mitsui Memorial Hospital |
| [ Summary ] | As patients with diabetes and/or high age become common in chronic dialysis patients, atherosclerotic diseases increase in number even in those who just started their dialysis life. Vascular calcification is very common in dialysis patients and is related to severe stenotic lesions. Treatment of ischemic heart diseases consists of timely diagnosis using coronary angiogram and appropriate intervention using medication, catheter intervention or coronary bypass surgery. However micro vascular diseases are often difficult to treat. Arteriosclerotic obstruction of peripheral artery is also debilitating disease for dialysis patients. Catheter intervention and surgical bypass are also effective in many patients. New treatment of micro vascular disease by revascularization with angiogenesis mechanism using vascular growth factors or their gene is now under clinical research. The revascularization of tissue biologically via medical or gene therapy will be a major advance in the treatment of patients with a diffuse disease and those who do not merit from conventional revascularization technique. Vascular gene therapies should probably become a very effective and practical therapeutic measure in near future. |
|