| Theme | The impact of bone and Ca/Pi metabolism on vascular disease | |
|---|---|---|
| Title | Pathology of calcification in long term hemodialysis | |
| Publish Date | 2003/10 | |
| Author | Makio Kawakami | Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author | Hiraku Yoshida | Department of Nephrology, Tokyo Jikei Medical University |
| Author | Masafumi Suzuki | Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author | Toru Harada | Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author | Kaoru Iwabuchi | Department of Pathology, Clinical Service, Tokyo Jikei Medical University |
| Author | Keitaro Yokoyama | Department of Nephrology, Tokyo Jikei Medical University |
| Author | Yoshindo Kawaguchi | Department of Nephrology, Tokyo Jikei Medical University |
| [ Summary ] | The calcification of the cardiac valves, the coronary artery and the aorta were examined in 664 autospsy cases including dialysed, non-dialysed uremics and a control group. The following results were found: (1) the low correlation of BUN and creatinine in contrast to Ca and P favoring calcification, (2) high predisposition to intereferance by diabetic and hypertensive factors, (3) a significant effect on length of exposure to hypertension and dialysis became clear. As to dialysis properties, we noted the following points: (4) initial ameriolation of heart load, eventually (after 6 years) resulted in severe decompensation, (5) a steady rise in blood Ca, and (6) periodic acceleration of calcification over 6 years, from long-term dialysis. These facts suggest that the bony and muscular site of dynamic Ca-metabolism is extended toward the highly Ca-exposed space in the mesenchymal portion, along the proximal arterial wall to the peripheral vasculature in tachytrophic organs. |
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