| Theme | Recent progress in parathyroid hormone research | |
|---|---|---|
| Title | PTH as a uremic toxin | |
| Publish Date | 2003/04 | |
| Author | Toshimitsu Niwa | Department of Clinical Preventive Medicine, Nagoya University Hospital |
| [ Summary ] | Patients with chronic renal failure exhibit hypocalcemia and hyperphosphatemia, which stimulate parathyroid glands to cause hyperplasia, and finally hyper parathyroidism. Excess secretion of PTH which induces fibrous ostitis, is a principal cause of renal osteodystrophy. Excess secretion of PTH induces high intracytosolic Ca concentration in several tissues, and are associated with the pathogenesis of cardiomyopathy, myopathy, encephaloneuropathy, dialysis dementia hyperlipidemia, glucose intolerance, impaired insulin secretion, anemia, bleeding tendency, impaired immunity, soft tissue calcification, soft tissue necrosis, pruritis, and sexual disturbance. Thus, PTH is a general uremic toxin. |
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