| Theme | Recent progress in parathyroid hormone research | |
|---|---|---|
| Title | Genetic abnormalities in parathyroid tumorigenesis | |
| Publish Date | 2003/04 | |
| Author | Hideki Tahara | Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| Author | Yoshiki Nishizawa | Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] | The molecular basis of parathyroid adenomatosis includes defects in the cyclin D1 and MEN1 genes but is, in large part, unknown. Furthermore, the molecular pathway of monoclonal growth of the parathyroid glands in uremic patients is poorly understood. To identify new locations of candidate parathyroid oncogenes or tumor suppressor genes, molecular allelotyping and new molecular technique, CGH, have been performed. | |