| Theme | Recent progress in parathyroid hormone research | |
|---|---|---|
| Title | Physiologic actions of PTHrP | |
| Publish Date | 2003/04 | |
| Author | Shinsuke Ohba | Unit of Bone and Cartilage Regeneration, University of Tokyo School of Medicine |
| Author | Yuichi Tei/CHUNG Ung-il | Unit of Bone and Cartilage Regeneration, University of Tokyo School of Medicine |
| [ Summary ] | PTHrP functions mainly locally as a paracrine/autocrine factor, while PTH works as an endocrine hormone. Studies of PTHrP-/- mice revealed that PTHrP regulates differentiation of growth plate chondrocytes. Subsequent studies of transgenic mice overexpressing PTHrP in cartilage and rescued PTHrP-knockout mice showed that it also plays an important role in other tissues. This article focuses on recently discovered variable physiological functions of PTHrP. | |