| Theme | Recent progress in parathyroid hormone research | |
|---|---|---|
| Title | Actions of PTH | |
| Publish Date | 2003/04 | |
| Author | Seiji Fukumoto | Department of Laboratory Medicine, University of Tokyo Hospital |
| [ Summary ] | Parathyroid hormone (PTH) plays pivotal roles in maintaining serum calcium level by acting on PTH1 receptor in kidney and bone. In addition, PTH has stimulatory effect on bone formation. Signal transduction system through PTH1 receptor is controlled by many complex mechanisms. Abnormalities in this system cause disturbed chondrocyte differentiation in addition to derangement of calcium metabolism. | |