Theme | Topics in calcium and phosphate transport | |
---|---|---|
Title | echanisms of intestinal inorgaic phosphate transport | |
Publish Date | 2002/10 | |
Author | Kanako Katai | Department of Food Science and Nutrition, Doshisha Women's College of Liberal Arts, Faculty of Human Life Science |
Author | Teruko Nakasa | Department of Food Science and Nutrition, Doshisha Women's College of Liberal Arts, Faculty of Human Life Science |
Author | Yasushi Okinaka | Department of Food Science and Nutrition, Doshisha Women's College of Liberal Arts, Faculty of Human Life Science |
[ Summary ] | The intestinal phosphate (Pi) transport process occurs through a sodium-independent, nonsaturable process and via an active, sodium-dependent component of Pi absorption, mainly in the duodenum and the jejunum. Intestinal Pi transport activity is well known to be controllable by pH, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and dietary phosphate. The stimulation of intestinal Na/Pi cotransport by low Pi diet and 1,25 (OH)2D3 can be explained by an increased amount of type IIb Na/Pi cotransporters in the brush-border membrane. In chronic renal failure (CRF), the current therapy for hyperphosphataemia consists of the administration of Pi binders. Pi binders reduce intestinal Pi absorption, but have several side effects. New and safe foods (drugs) which can inhibit intestinal Pi transport should thus be elucidated. |