| Theme | Hyperphosphatemia | |
|---|---|---|
| Title | Mechanism and regulation of intestinal phosphate absorption | |
| Publish Date | 2002/01 | |
| Author | Seiji Fukumoto | Department of Laboratory Medicine, University of Tokyo |
| [ Summary ] | Intestinal absorption of phosphate is mediated by two mechanisms, passive diffusion according to the concentration gradient and active sodium-dependent absorption. Two major stimulants of phosphate absorption, phosphate deprivation and 1,25-dihydroxyvitamin D, enhance sodium-dependent phosphate absorption. However, the mechanisms for the stimulation of phosphate absorption by these factors may be different. Type IIb sodium-phosphate cotransporter has been cloned as a possible mediator of sodium-dependent intestinal absorption of phosphate. The physiological role of this transporter remains to be elucidated. |
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