| Theme | Hyperphosphatemia | |
|---|---|---|
| Title | Molecular biology of sodium dependent phosphate transporter | |
| Publish Date | 2002/01 | |
| Author | Eiji Takeda | Department of Clinical Nutrition, School of Medicine, The University of Tokushima |
| Author | Megumi Iida | Department of Clinical Nutrition, School of Medicine, The University of Tokushima |
| Author | Kumi Kobayashi | Department of Clinical Nutrition, School of Medicine, The University of Tokushima |
| [ Summary ] | Phosphate homeostasis and plasma phosphate concentration depend primarily on the amount of renal typeII phosphate transporter (NPT- 2) that regulate tubular phosphate transport. Expression of NPT-2 on the brush border membrane is regulated by transcriptional level of NPT-2 gene and NPT-2 translocation. The analysis of murine and human 5ยด-promotor region in NPT-2 gene showed the sequences which bind transcription factors such as vitamin D receptor and others. Regulation by intracellular translocation of NPT-2 by parathyroid hormone has been shown to be mediated by a chloride channel (CLC-5) expressed in renal endosomes. Because the internalization of the NPT-2 is affected in Dent's disease caused by mutations in CLC-5. | |