| Theme | Hyperphosphatemia | |
|---|---|---|
| Title | Phosphate sensor in the body | |
| Publish Date | 2002/01 | |
| Author | Masashi Kuwahata | Department of Nutritional Science, School of Medicine, Tokushima University |
| Author | Hiroko Segawa | Department of Nutritional Science, School of Medicine, Tokushima University |
| Author | Mikiko Ito | Department of Nutritional Science, School of Medicine, Tokushima University |
| Author | Ken-ichi Miyamoto | Department of Nutritional Science, School of Medicine, Tokushima University |
| [ Summary ] | The regulation of inorganic phosphate (Pi) in the human body is controlled mainly by reabsorption in the proximal tubules of the kidney. Dietary Pi is an important regulator for renal Pi reabsorption. The type II sodium-dependent phosphate transporters (NPT2) are located at the apical membranes of renal proximal tubular cells and major functional transporters associated with renal Pi reabsorption. We demonstrated that TFE3 may participate in the transcriptional regulation of the NPT2 gene by dietary Pi. Interestingly, infusion of Pi in the third ventricle of the brains of Pi-deprived animals resulted the down-regulation of the NPT2 protein in the kidney. The central control (Pi sensor in the brain) of peripheral Pi transport may be an important mechanism for regulation of Pi homeostasis. | |