| Theme | Calcitonin -- update | |
|---|---|---|
| Title | Efficacy of calcitonin on osteoporosis | |
| Publish Date | 2001/10 | |
| Author | Masashi Okuro | Department of Geriatric Medicine, Osaka University Medical School |
| Author | Shigeto Morimoto | Department of Geriatric Medicine, Osaka University Medical School |
| Author | Toshio Ogihara | Department of Geriatric Medicine, Osaka University Medical School |
| [ Summary ] | Calcitonin (CT) is relatively safe medicine, and synthetic eel-or salmon CT is used for osteoporosis. The efficacy of this hypocalcemic hormone is due to inhibition of bone resorption, thus it is used mainly for high-turn over-type osteoporosis with high levels of serumalkaline phosphatase, and urinary excretions of calcium and deoxypiridinorin, such as postmenopausal osteoporosis and/or osteoporosis due to immobilization. Relatively low dose, 10U twice a week or 20U once a week, is used in Japan. Efficacy of long-term administration of CT should be ascertained, because escape phenomenon of the hormone has been reported. | |