| Theme | Calcitonin -- update | |
|---|---|---|
| Title | Structure and function of calcitonin and its receptor | |
| Publish Date | 2001/10 | |
| Author | Seiji Fukumoto | Department of Laboratory Medicine, University of Tokyo Hospital |
| [ Summary ] | Calcitonin was initially identified as a hypocalcemic factor and later turned out to be a neuropeptide as well. Calcitonin gene-related peptide, amylin and adrenomedullin are related peptides to calcitonin and reported to mediate diverse biological functions. Receptors for these peptides constitute a subfamily of G protein-coupled receptors and recently shown to obtain responsiveness to different ligands by interactions with receotor-activity modifying proteins. | |