| Theme | Frontiers in Vitamin D Action | |
|---|---|---|
| Title | Functions of vitamin D receptor on cartilage development | |
| Publish Date | 2001/04 | |
| Author | Keisuke Sekine | Institute of Molecular and Cellular Biosciences, The University of Tokyo |
| Author | Yoko Yamamoto | Institute of Molecular and Cellular Biosciences, The University of Tokyo |
| Author | Shigeaki Kato | Institute of Molecular and Cellular Biosciences, The University of Tokyo |
| [ Summary ] | In the steps of bone development in vertebrate,there are two types of bone formation, i.e. endochondral ossification and intramembranous ossification. Endochondral ossification is a major process, which forms most skeletal structures. The first event is chondrocyte generation, following replacement of chondrocyte into bone with ossification. Understanding of the processes in not only bone development, but also cartilage development regulating factors is very important. However molecular mechanisms of cartilage development and differentiation are largely unknown. In this review, 1) recent understanding of molecules with critical roles on chondrogenic differentiation, 2) action of vitamin D on cartilage differentiation will be discussed. Especially on the basis of analysis of VDR KO mice, discovered disorders in VDR KO mice related with impaired formation of bone and hypertrophic chondrocyte are described. |
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