| Theme | Frontiers in Vitamin D Action | |
|---|---|---|
| Title | Vitamin D action on parathyroid gland | |
| Publish Date | 2001/04 | |
| Author | Shozo Yano | Division of Dialysis and Metabolism, Kobe University School of Medicine |
| Author | Tatsuo Tsukamoto | Third Division, Department of Medicine, Kobe University School of Medicine |
| [ Summary ] | Vitamin D negatively regulates parathyroid hormone (PTH) synthesis and secretion as well as parathyroid cell growth in patients with chronic renal failure. This feedback action of the active vitamin D metabolites mediates not only through vitamin D receptor as genetic action, but also via serum calcium level, which is another strong regulator through calcium-sensing receptor in parathyroid cells. Here, we review the molecular mechanism and action of vitamin D, including newly developed vitamin D analogs, from the therapeutic view point of renal hyperparathyroidism. | |