| Theme | Dialysis -- related amyloidosis -- update | |
|---|---|---|
| Title | Pathophysiological role of advanced glycation /lipoxidation end products (AGEs/ALEs) in dialysis-related amyloidosis | |
| Publish Date | 2001/01 | |
| Author | Reiko Inagi | Institute of Medical Sciences and Department of Medicine, Tokai Uiversity School of Medicine |
| Author | Toshio Miyata | Institute of Medical Sciences and Department of Medicine, Tokai Uiversity School of Medicine |
| Author | Kiyoshi Kurokawa | Institute of Medical Sciences and Department of Medicine, Tokai Uiversity School of Medicine |
| [ Summary ] | In the development of amyloidosis, two stages are considered:asymptomatic early stage and clinical and radiological evident late stage. This article discusses the recent progresses in the understanding of the pathological significance of irreversible, nonenzymatic protein modifications (AGEs/ALEs) in Beta2-microglobulin amyloid. | |