| Theme | Evidence and issue for clinical practice of acute kidney injury | |
|---|---|---|
| Title | AKI to CKD crosstalk | |
| Publish Date | 2019/06 | |
| Author | Keiko Yano | Department of Nephrology, Graduate School of Medicine, Kyoto University |
| Author | Yuki Sato | Department of Nephrology, Graduate School of Medicine, Kyoto University |
| Author | Motoko Yanagita | Department of Nephrology, Graduate School of Medicine, Kyoto University |
| [ Summary ] | Recent clinical studies have demonstrated that acute kidney injury (AKI) often progresses to chronic kidney disease (CKD). Although proximal tubule injury play a pivotal role in AKI, it also leads to glomerular sclerosis, renal fibrosis, and anemia in animal models. Whether AKI progresses to CKD is determined by several factors such as severity and frequency of AKI, as well as the decline of renal function reserve (RFR) of the host. RFR represents the capacity of the kidney to increase its glomerular filtration rate (GFR) in response to certain physiological stimuli. RFR declines before baseline GFR declines, and therefore RFR is thought to reflect renal function more precisely. In this article, we describe the current understanding of pathophysiology of AKI to CKD progression and RFR as a marker for renal function. | |