| Theme | Current topics in medical engineering technologies for dialysis therapy | |
|---|---|---|
| Title | Current status and perspective of online hemodiafiltration therapy | |
| Publish Date | 2019/05 | |
| Author | Tadashi Tomo | Clinical Engineering Reserch Center, Faculty of Medicine, Oita University |
| [ Summary ] | The number of online hemodiafiltration (HDF) patients in Japan has increased dramatically since 2012. As of December 31, 2017, 70,604 patients are being treated with online HDF and 17,105 patients (treated with I-HDF) have been added, for a total of 87,709. The majority of patients have been treated by pre-dilution mode online HDF. The patients being treated with the new I-HDF modality are increasing. Many reports published in Europe have examined the effect of online HDF on the prognosis of dialysis patients; however, each reported only on post-dilution mode. However, there is one report on the prognostic effect of predilution mode HDF from Japan. There is little evidence of the factors that define the therapeutic effect of online HDF and few reports on substitution fluid amount. Knowledge of the correlation between active removal of middle-molecular-weight solute and protein-bound toxin, the original objective of online HDF, and the clinical effect and improvement in prognosis is desired. |
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