| Theme | Electrolyte and acid-base disorders in dialysis patients | |
|---|---|---|
| Title | The history and future perspectives of the dialysate for hemodialysis therapy | |
| Publish Date | 2019/02 | |
| Author | Michio Mineshima | Department of Clinical Engineering, Tokyo Women's Medical University |
| [ Summary ] | For hemodialysis therapy, the dialysate strongly depends on the types of alkaline agents. There are three types of dialysate: acetate dialysate (first generation), bicarbonate dialysate (second generation), and non-acetic bicarbonate dialysate (third generation). The driving force of solute transport through the dialysis membrane based on molecular diffusion is the difference of solute concentration between blood and dialysate sides. Namely, the solute transfer rate through the membrane is dependent of the solute concentration in the dialysate. On the other hand, the transfer rate depends on the ultrafiltration flow rate of solutes, such as Na, having small concentration differences between the blood and dialysate. In the future, real-time monitoring of patient condition and device performance during the hemodialysis treatment will allow for adequate dialysis of patient by changing the compounding and/or diluting ratio of dialysis agents based on an automatic control method. |
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