| Theme | Electrolyte and acid-base disorders in dialysis patients | |
|---|---|---|
| Title | Electrolyte and acid-base physiology in chronic kidney disease | |
| Publish Date | 2019/02 | |
| Author | Tatsuru Ota | Department of Medical Radiology, Faculty of Medical Technology, Teikyo University / Department of Internal Medicine, Teikyo University School of Medicine |
| [ Summary ] | Electrolyte and acid-base physiology is essential for diagnosis and treatment of various disorders in chronic kidney disease (CKD). The concentration of hydrogen ions (H+) is very low level, and needs to be strictly regulated within a very low range for maintaining biological homeostasis. The mechanisms of acids accumulation in renal insufficiency are complicated and associated with the balance between acid-base production and excretion, the buffering systems, and kidney functions. Metabolic acidosis is responsible for protein metabolism, hyperkalemia, and cardiovascular disorders, resulting in the progression of CKD. Alkali therapy for acidosis with sodium bicarbonate or others is important and recommended to prevent end-stage renal disease. | |