| [ Summary ] |
Practical guidelines about acute kidney injury (AKI) have been published and include the definition of neonatal AKI. Although there are concerns about this definition, these guidelines have standardized the definition of neonatal AKI for many subsequent reports on neonatal AKI. Neonatal AKI strongly correlates with prematurity, and its incidence is 8-54 %. The main causes are hypovolemia, sepsis, neonatal asphyxia, medicines, and cardiac surgery. Neonatal AKI leads to poor short-and long-term outcomes, including mortality and morbidity. Some papers have reported high rates of AKI survivors progressing to hypertension, proteinuria, and CKD. Mechanisms of the development of CKD due to neonatal AKI involve nephron loss, glomerular hyper-filtration, and glomerulosclerosis. Kidney function tests of neonates with AKI should be initiated early in management of CKD and followed over a long period of time. |