| Theme | Outcomes of peritoneal dialysis treatment during the past half-century | |
|---|---|---|
| Title | Variations and characteristics of the peritoneal dialysis solutions | |
| Publish Date | 2018/12 | |
| Author | Minoru Ito | Department of Nephrology, Yabuki Hospital |
| [ Summary ] | Most current peritoneal dialysis (PD) solutions contain glucose as an osmotic agent. However, there is evidence that glucose-based solutions are associated with local and systemic toxicities. Conventional solutions shows low biocompatibility because of low pH and high glucose degradation product (GDP) generation. Therefore, neutral pH/low GDP and bicarbonate solutions are required. We can use neutral pH/low GDP solutions as the standard. These solutions show high biocompatibility and ability to preserve residual kidney function. Icodextrin solution is an alternative to glucose-based solutions and is associated with improvement of ultrafiltration. We consider the PD prescription pattern based on dialysis adequacy. The development of more biocompatible PD solutions is expected in the future. | |