| Theme | Approach for sarcopenia and frailty in chronic kidney disease | |
|---|---|---|
| Title | Pathogenic mechanisms of uremic sarcopenia in CKD | |
| Publish Date | 2015/07 | |
| Author | Takuya Yoshida | Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka |
| Author | Hiromichi Kumagai | Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka |
| [ Summary ] | The prevention and treatment of uremic sarcopenia is attracting attention to improve the prognoses for patients with chronic kidney disease (CKD). Muscle mass is preserved by the balance between protein synthesis pathway, insulin/insulin-like growth factor-1 (IGF-1) signaling, and the protein degradation pathways, the ubiquitin-proteasome system and myostatin. IGF-1 also plays a major role in muscle recovery and hypertrophy when muscle fibers are injured. In CKD patients, the IGF-1 signaling is decreased and the muscle catabolic pathway increases though various complications associated with CKD, including metabolic acidosis, malnutrition, infl ammation, insulin resistance and increased angiotensin II activity. Further studies are required to reveal the mechanisms driving uremic sarcopenia, and to develop new strategies for prevention and treatment of uremic sarcopenia. | |