| Theme | Testify the concepts of renal osteodystrophy and chronic kidney disease-bone and mineral disorder (CKD-MBD) | |
|---|---|---|
| Title | What kinds of CKD patients tend to be broken, and how to prevent it | |
| Publish Date | 2015/06 | |
| Author | Koji Matsuo | Division of Clinical Nephrology and Rheumatology, Niigata University Medical and Dental Hospital |
| Author | Junichiro James Kazama | Division of Blood Purification Therapy, Niigata University Medical and Dental Hospital |
| [ Summary ] | Chronic kidney disease (CKD) is known to be an independent risk factor for fracture. It is known that low bone mineral density (BMD), age, sex, past fracture history, smoking, alcohol consumption and among other factors are risk factors for fracture in the general population. In addition to these risk factors, past history of renal transplantation, bone mineral disorder, metabolic acidosis, accumulation of uremic toxins, inflammatory cytokines, homocysteine are risk factors for fractures in CKD patients, and they possibly lead to deterioration of bone quality directly or indirectly. For the prevention of fractures in CKD patients, we should manage chronic kidney disease-mineral and bone disorder (CKD-MBD) as well as consider the use of anti-osteoporotic drugs. However, as these interventions are not adequate for preventing fractures, new intervention methods are required. |
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