| Theme | Testify the concepts of renal osteodystrophy and chronic kidney disease-bone and mineral disorder (CKD-MBD) | |
|---|---|---|
| Title | Treatment with non-calcium based phosphate binders decreases mortality risk in CKD patients | |
| Publish Date | 2015/06 | |
| Author | Hiroki Hase | Division of Nephrology, Toho University Ohashi Medical Center |
| [ Summary ] | CKD patients experience vascular calcification more commonly than the general population contributing to increased cardiovascular risk. Pathomorphologically, calcified plaque forming atherosclerosis of the large elastic arteries and calcified medial thickening arteriosclerosis can be distinguished from each other. Intimal calcification of plaques is the most important risk factor for acute coronary syndrome and chronic myocardial ischemia. Medial calcification of large elastic arteries may be also an important risk factor for chronic myocardial ischemia. Treatment with non-calcium based phosphate binders is associated with a decreased risk of all-causes of mortality in CKD patients. The mechanisms may produce attenuated progression of pulse wave velocity and decreased serum FGF23 levels. | |