| Theme | Testify the concepts of renal osteodystrophy and chronic kidney disease-bone and mineral disorder (CKD-MBD) | |
|---|---|---|
| Title | Comparison between lanthanum carbonate and calcium carbonate on the progression of coronary artery calcification in hemodialysis patients | |
| Publish Date | 2015/06 | |
| Author | Takeyasu Ohtake | Department of Nephrology, Immunology and Vascular Medicine, Shonan Kamakura General Hospital |
| Author | Shuzo Kobayashi | Department of Nephrology, Immunology and Vascular Medicine, Shonan Kamakura General Hospital |
| [ Summary ] | Vascular calcification is an important independent predictor of cardiovascular events including cardiovascular related death, in patients receiving hemodialysis (HD). Calcium overloads due to the use of calcium-containing phosphate binders and hyperphosphatemia due to renal failure strongly promote the progression of vascular calcification in HD patients. There have been only a few reports evaluating the efficacy of lanthanum carbonate to it delay the progression of vascular calcification. We provide evidence that switching from phosphate binders to calcium carbonate or lanthanum carbonate significantly delays the progression of coronary artery calcification in HD patients. Use of non-calcium containing phosphate binder, especially lanthanum carbonate, produce beneficial effects in relation to arterial calcification, and probably also on inflammation and malnutrition, which are major atherosclerosis-associated factors observed in HD patients. |
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