| Theme | Early detection and prevention for cancer of dialysis patients | |
|---|---|---|
| Title | Renal cell carcinoma associated with acquired cystic disease of the kidney | |
| Publish Date | 2015/01 | |
| Author | Noriko Hayami | Nephrology Center, Toranomon Hospital |
| Author | Junichi Hoshino | Nephrology Center, Toranomon Hospital |
| [ Summary ] | It is known that dialysis patients have high incidence of renal cell carcinoma (RCC). Acquired cystic disease of the kidney (ACDK) is a risk factor for RCC. ACDK increases as dialysis periods become longer ACDK exists in over 90 % of dialysis patients who have been treated for ten years or more. As a result, the incidence of RCC increases in long-term dialysis patients. Screening for RCC is important because the prognosis for patients with RCC who are asymptomatic is better than for those with symptoms. Acquired cystic disease-associated RCC (ACD-associated RCC) is the most common subtype of RCC in patients with ACDK. Clear-cell papillary and papillary RCC are common subtypes in these patients. Diagnosis of RCC in patients with ACDK may be difficult because these histologic subtypes may not exhibit typical masses when observed with enhanced CT, even though there may be ACDK. Radical surgery should be performed, if possible. There is a choice of medical treatments including molecular target drugs when radical surgery is difficult. | |