| Theme | Glycemic Control and Diabetes with Chronic Kidney Disease | |
|---|---|---|
| Title | Glucose concentration of dialysate | |
| Publish Date | 2012/02 | |
| Author | Yoshimitsu Hayashi | Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine |
| Author | Masaaki Nakayama | Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine |
| [ Summary ] | Concentrations of glucose in dialysates is usually set at 100-150 mg/dL in order to prevent hypoglycemia during in hemodialysis. However, hemodialysis induced hypoglycemia is still observed in a certain patients. This phenomenon is probably related to elevations of glucose uptake in red blood cells and impaired gluconeogenesis in the kidneys in end-stage renal disease (ESRD) patient. On the other hand, concentrations of glucose in peritoneal dialysis fluids are set at 1.5-2.5 % to increase osmotic pressure to provide ultrafi ltration. Glucose absorption during peritoneal dialysis has signifi cant effects on glucose and lipid metabolism especially in diabetic patients and high transporters. These metabolic abnormalities are somewhat induced by iatrogenic factors. Thus, we should provide medical care keeping in mind dialysis induced glucose and lipid metabolic abnormalities. | |