| Theme | Prospects for Hemodiafiltration | |
|---|---|---|
| Title | Internal filtration enhanced hemodialysis | |
| Publish Date | 2011/05 | |
| Author | Michio Mineshima | Department of Clinical Engineering, Tokyo Women's Medical University |
| [ Summary ] | Internal filtration enhanced hemodialysis (IFEHD) has been introduced as a means of improving the efficiency of solute removal in conventional hemodialysis therapy. Enhanced internal filtration has increased the convective transport of solutes in addition to diffusive transport. It is expected that similar solute removal characteristics will be obtained in IFEHD with hemodiafiltration (HDF) therapy. An analytical study using a numerical model for solute transport in dialyzers was carried out to compare the solute removal characteristics of IFEHD to HDF with post-dilution mode. A simulation analysis was done by inputting the observed values of internal filtration flow rates measured by Doppler ultrasonography into the numerical model. β2-microglobulin removal in HDF with post-dilution was superior to that obtained in IFEHD under the same filtration flow rates because of the lack of back-filtration seen in HDF therapy. It was estimated that the solute removal efficiency available in IFEHD therapy is equivalent to that provided with HDF employing smaller amounts (<5 l/session) of replacement fluid. |
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