| Theme | Apheresis Update | |
|---|---|---|
| Title | Apheresis therapy for kidney transplantation | |
| Publish Date | 2011/11 | |
| Author | Yuki Nakagawa | Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Kazuhide Saito | Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Kazuei Narita | Division of Clinical Nephrology and Rheumatology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University |
| Author | Kota Takahashi | Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University |
| [ Summary ] | Renal failure patients often experience a state of the uremia. They may also face various conditions such as excessive water retention, electrolyte disorders, acid and base equilibrium disturbances, and anemia. Dialysis management to correct these conditions, along with frequent inspection of their condition should be done before kidney transplantation. Moreover, those receiving ABO incompatible kidney transplants and recipients having donor-specific antibodies (DSA) require plasma exchange (PEX) and double filtration plasmapheresis (DFPP). Immunoadsorption is required before transplants to control acute antibody-mediated rejection (acute AMR) in the postoperative period. In addition, recipients who have focal sclerosing glomerulonephritis (FSGS) need plasmapheresis before transplantation to prevent relapse. A variety of apheresis therapies required for kidney transplantations are described. | |