| Theme | Apheresis Update | |
|---|---|---|
| Title | Apheresis for treatment of skin diseases | |
| Publish Date | 2011/11 | |
| Author | Hiromichi Yamada | Department of Dermatology, International Goodwill Hospital |
| Author | Kenji Takamori | Juntendo University Urayasu Hospital |
| [ Summary ] | Toxic epidermal necrolysis (TEN) treated with plasma exchange (PEX), pyoderma gangrenosum and pustular psoriasis treated with granulocytapheresis (GCAP) or leukocytapheresis (LCAP) are described. Seventy five TEN patients were treated with PEX. The efficacy of PEX for the treatment of TEN was as follows : excellent in 44 cases, good in 21 cases, fair in 3 cases, no effect in 6 cases. The rate of effectiveness was 86.7 % and the mortality rate was 17.3 %. PEX was found to be an effective treatment for TEN. Thirty two pyoderma gangrenosum patients were treated with GCAP or LCAP. The efficacy of GCAP/LCAP for the treatment of pyoderma gangrenosum was as follows : excellent in 8 cases, good in 22 cases, fair in 2 cases, no effect in 0 cases. The rate of effectiveness was 93.8 %. GCAP/LCAP were found to be effective treatments for pyoderma gangrenosum. Twenty two pustular psoriasis patients were treated with GCAP or LCAP. The efficacy of GCAP/LCAP for the treatment of pustular psoriasis was as follows：excellent in 3 cases, good in 10 cases, fair in 5 cases, no effect in 4 cases. The rate of effectiveness was 59.1 %. |
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