| Theme | How Should We Step up the Future Dialysis Therapy in Japan ? | |
|---|---|---|
| Title | Management for chronic kidney disease-mineral and bone disorder | |
| Publish Date | 2010/07 | |
| Author | Takatoshi Kakuta | Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine |
| [ Summary ] | The concept of bone disease in dialysis patient has shifted from ROD to CKD-MBD as a systemic disease. Coronary artery calcification often occurs in dialysis patients and is predictive of cardiovascular morbidity and mortality in end-stage renal disease (ESRD) patients. Disturbed mineral metabolism assumes particular importance in vascular calcification in ESRD patients. Increased serum phosphorus and calcium, and calcium×phosphorus product in dialysis patients are independently associated with an increased risk of arterial calcification and of cardiovascular mortality. Kidney Disease : Improving Global Outcomes (KDIGO) proposed a pathologic model for CKD-mineral and bone disorder (CKD-MBD). A pathologic model for CKD-MBD and CKD-related bone diseases is proposed. | |