| Theme | Heart and it's Diseases in Dialysis Patients -- For their better longevity | |
|---|---|---|
| Title | Heart failure and pulmonary circulation | |
| Publish Date | 2010/05 | |
| Author | Seiji Koga | Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences |
| Author | Satoshi Ikeda | Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences |
| Author | Koji Maemura | Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences |
| [ Summary ] | Pulmonary circulation has unique anatomical, physiological, and functional characteristics different from systemic circulation. Pulmonary arterial pressure (PAP) can be maintained below 15 mmHg, opposing increases in pulmonary blood flow, by lowering pulmonary vascular resistance (PVR) through distension and recruitment of pulmonary capillary vessels. Pulmonary hypertension (PH) is defined as a mean PAP greater than 25 mmHg at rest. PH owing to left heart diseases is induced by higher pulmonary venous pressure due to increased left end-diastolic or left atrial pressure, which can cause pulmonary edema. PH owing to chronic lung diseases is induced by increased PVR due to hypoxic pulmonary vasoconstriction and obliteration of the vascular bed, which can lead to right-sided heart failure and cor pulmonale. | |