| Theme | Heart and it's Diseases in Dialysis Patients -- For their better longevity | |
|---|---|---|
| Title | Cardiac pathology of long-term dialysis | |
| Publish Date | 2010/05 | |
| Author | Makio Kawakami | Department of Pathology, Seirei Sakura Hospital |
| Author | Hiraku Yoshida | Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine |
| Author | Masaaki Nakayama | Research Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine |
| Author | Masahiro Ikegami | Department of Pathology, Clinical Service, The Jikei University School of Medicine |
| Author | Yoshindo Kawaguchi | Division of Nephrology and Hypertension, The Jikei University School of Medicine/Kanagawa Prefectual Shiomidai Hospital |
| [ Summary ] | The heart consists of two elements. The first element may be thought of as an "engine" (A), due to its function in providing circulatory motive power. The secondary cardiac functions may be considered to be "supportive" (B). Because of its roles in producing glomerular ultrafiltrates and controlling renal blood flow, the heart is burdened with the tasks of modulating both blood pressure and volume. It is hoped that therapeutic intervention with hemo or peritoneal dialysis may provide some relief for stress placed on the heart. However, that treatment modality may lead to increased ventricular dilatative hypertroghy. Diffuse collagenosis and cardiac degeneration may occur at exponentially, increasing rates in the later phases of circulatory failure (A). Valvular and coronary sclerosis may be potentiated in a linear fashion in the "supportive" functions of the heart (B). The observed results of changes in cardiac function, in relation to duration of dialysis therapy, have laid the foundation for implementation of the term "dialysed heart" as a refinement of the term "uremic heart". |
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