The Japanese Journal of Clinical Dialysis Vol.26 No.4(3-4)

Theme Performance Evaluations for Blood Purification Devices and Characteristics of Dialysis Adequacy Indices
Title A 3×6-8 hr HD with unrestricted diet using low blood flow and large dialysis membranes：It allows adequate removal of phosphorus and β2-microglobulin, but less removal of amino acid and albumin
Publish Date 2010/04
Author Hiroshi Kaneda Kamome Clinic
Author Hiroyasu Uchida Kamome Clinic
[ Summary ] A 6-8 hr long hemodialysis (HD) with unrestricted diet using low blood flow (QB, mean 144 ml/min) and large dialysis membranes (mean 2.3 m2) contributes to better survival rates and less troublesome symptoms during and after HD. This dialysis modality was developed and implemented in 1998 by Kaneda (termed Kaneda's formula). In this formula, solute excretion was tested in nightly 8 hr HD patients. Loss of amino acids and albumin during 8 hr HD with 100 ml/min of QB were slight compared to those of 8 hr HD with 170 ml/min of QB or 4 hr conventional HD with more than 200 ml/min of QB. On the other hand, loss of phosphorus and β2 microglobulin during 8 hr HD were much higher compared to those of 4 hr conventional HD with more than 200 ml/min of QB.
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