| Theme | Performance Evaluations for Blood Purification Devices and Characteristics of Dialysis Adequacy Indices | |
|---|---|---|
| Title | Time related of dialyzer performance reduction | |
| Publish Date | 2010/04 | |
| Author | Ryoichi Sakiyama | Department of Clinical Engineering, Tokyo Women's Medical University |
| Author | Michio Mineshima | Department of Clinical Engineering, Tokyo Women's Medical University |
| [ Summary ] | Several kinds of high-flux dialyzers have been developed to improve solute removal efficiency and water permeability for hemodialysis therapy. The performance of those dialyzers, however, often decreases with time due to membrane fouling, namely protein plugging to the membranes. The rate of reductions in dialyzer performance in high-flux dialyzers was evaluated during a bovine in vitro study and a clinical study. As a result, internal filtration rates (QIF) and clearance of large molecular weight substances such as those being α1-MG in size and albumin gradually decreased with time up to 120 min after the start of the experiments in the in vitro study. These results were induced by membrane fouling, but the effects on solute transport through the membrane were different in various solutes. In a clinical study, increases in TMP and decrease in QIF over time were observed to be similar to those observed in the in vitro study. High flux dialyzers should be used for individual patients in consideration their reduced performance over time. |
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