| Theme | Acute Blood Purification Therapy | |
|---|---|---|
| Title | Sustained low efficiency dialysis (SLED) | |
| Publish Date | 2010/09 | |
| Author | Mayumi Mori | Division of Nephrology, Department of Medicine, St. Luke's International Hospital |
| Author | Yusuke Tsugawa | Division of Nephrology, Department of Medicine, St. Luke's International Hospital |
| Author | Yasuhiro Komatsu | Division of Nephrology, Department of Medicine, St. Luke's International Hospital |
| [ Summary ] | Continuous renal replacement therapy is the preferred modality for critically ill unstable patients. However, intermittent hemodialysis is the choice for stable chronic renal failure patients. While there is a positive impact on preservation of blood pressure with continuous therapy, resulting survival benefits observed in intensive care units have yet to be proven. Sustained low efficiency dialysis (SLED) is a novel renal replacement therapy with a broad range of adjustability of solutes and volume removal. This modality combines the advantages of intermittent and continuous renal replacement therapy. Owing to the advantages of flexible treatment timing and reduced costs, SLED can be used as the preferred mode of extracorporeal renal replacement therapy in intensive care units. Except for hemodynamically unstable patients with cardiac comorbidity, SLED can be a promising treatment option for the majority of patients in intensive care units. We review basic concepts and current usage of SLED. | |