| Theme | Achieving Adequate Dialysis Prescription for Individual Patients | |
|---|---|---|
| Title | Selection of dialyzer removability and biocompatibility | |
| Publish Date | 2009/05 | |
| Author | Tadashi Tomo | Department of Internal Medicine II, Faculty of Medicine, Oita University |
| [ Summary ] | There is no significant difference between the removal ability of any of the Beta2 MG dialyzers primarily employed for HD treatment in Japan. The removal ability of dialyzers is determined by their capacity to eliminate low molecular weight proteins or those with molecular weights in the range of 30,000 or albumin leakage. Dialyzers with albumin leaking properties are thought to be effective in the removal of albumin bound uremic toxins and improving the appetite of dialyzed patients by removing leptin. In cases where albumin leaking dialyzers are used, careful observation of the nutritional status of patients should be carried out. Most dialyzers used for HD treatment in Japan are of the synthetic high molecular weight membrane material type. The biocompatibilities of these dialyzers have been improved compared to cuprophan dialyzers. The problems with PVP in PS dialyzers are discussed. There have been several reports concerning the improved effects on nutritional status of patients through use of EVAL or PMMA dialyzers. Further use of these dialyzers for senile or undernourished patients is expected in the future. In selecting dialyzers, it is important to keep in mind the influence of their removal ability and biocompatibility in relation to the nutritional status of patients. |
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