| Theme | Evolution in Management of Renal Anemia | |
|---|---|---|
| Title | Protective effects of erythropoietin on peripheral arteries | |
| Publish Date | 2008/01 | |
| Author | Shigetaka Shimodaira | Division of Transfusion Medicine, Shinshu University Hospital |
| Author | Daisuke Fukui | Department of Cardiovascular Surgery, Shinshu University School of Medicine |
| Author | Megumi Koshikawa | Division of Transfusion Medicine, Shinshu University Hospital / Department of Cardiovascular Medicine, Shinshu University School of Medicine |
| Author | Uichi Ikeda | Department of Cardiovascular Medicine, Shinshu University School of Medicine |
| Author | Jun Amano | Department of Cardiovascular Surgery, Shinshu University School of Medicine |
| [ Summary ] | EPO receptors have been detected in the cardiovascular system including the vascular endothelium, vascular smooth muscles, and cardiac muscles along with erythroid lineage. There are in situ autocrine or paracrine mechanisms other than the hormonal reactions of EPO. EPO physiologically acts to prevent apoptosis, mitogenic reactions and angiogenesis on blood vessels, leading to the maintainance of homeostasis with tissue ischemia. There would be a local release of EPO from marrow macrophages and erythroblasts through therapeutic angiogenesis if bone marrow cells were implemented. The cellular cocktail discharging various factors including EPO, may with an increase of time, contribute to neovasclarization. It is necessary to consider the effect of adverse events on the cardiovascular system by comparing clinical benefits in cases where there has been administration of recombinant human EPO. |
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